The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Jul. 20, 2011
Ravinder Reddy, Gladwyne, PA (US);
Hari Hariharan, Mount Laurel, NJ (US);
Mohammad Haris, Philadelphia, PA (US);
Kejia Cai, Elkins Park, PA (US);
Anup Singh, Philadelphia, PA (US);
Feliks Kogan, Philadelphia, PA (US);
Ravinder Reddy, Gladwyne, PA (US);
Hari Hariharan, Mount Laurel, NJ (US);
Mohammad Haris, Philadelphia, PA (US);
Kejia Cai, Elkins Park, PA (US);
Anup Singh, Philadelphia, PA (US);
Feliks Kogan, Philadelphia, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging.