The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Nov. 01, 2006
Applicants:
Randolph J. Noelle, Plainfield, NH (US);
Li-fan LU, Seattle, WA (US);
Cory L. Ahonen, Enfield, NH (US);
Inventors:
Randolph J. Noelle, Plainfield, NH (US);
Li-Fan Lu, Seattle, WA (US);
Cory L. Ahonen, Enfield, NH (US);
Assignee:
Trustees of Dartmouth College, Hanover, NH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61K 39/38 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention is a method for inhibiting Tcell functional activities by blocking Tcell-mediated mast cell activation. It has been found IL-9 produced by Tcells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject.