The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2014
Filed:
Jun. 21, 2012
Stefano Colloca, Rome, IT;
Alfredo Nicosia, Rome, IT;
Agostino Cirillo, Rome, IT;
Bruno Bruni Ercole, Rome, IT;
Annalisa Meola, Rome, IT;
Paolo Palazzolo, Rome, IT;
Stefano Colloca, Rome, IT;
Alfredo Nicosia, Rome, IT;
Elisabetta Sporeno, Rome, IT;
Agostino Cirillo, Rome, IT;
Bruno Bruni Ercole, Rome, IT;
Annalisa Meola, Rome, IT;
MSD Italia SRL, Rome, IT;
Abstract
The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.