The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2014
Filed:
Apr. 16, 2009
Roland Contreras, Merelbeke, BE;
Nico L. M. Callewaert, Lichtervelde, BE;
Steven C. J. Geysens, Kruishoutem, BE;
Roland Contreras, Merelbeke, BE;
Nico L. M. Callewaert, Lichtervelde, BE;
Steven C. J. Geysens, Kruishoutem, BE;
VIB, VZW, Zwijnaarde, BE;
Research Corporation Technologies, Inc., Tucscon, AZ (US);
Universiteit Gent, Ghent, BE;
Abstract
The present invention provides genetically engineered strains ofcapable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an α-1,2-mannosidase and glucosidase II. The genetically engineered strains of the present invention can be further modified such that the OCH1 gene is disrupted. Methods of producing glycoproteins with reduced glycosylation using such genetically engineered stains ofare also provided.