The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Jun. 06, 2008
Binghe Wang, Marietta, GA (US);
Nanting NI, Atlanta, GA (US);
Junfeng Wang, Beijing, CN;
Chung-dar LU, Roswell, GA (US);
Han-ting Chou, Atlanta, GA (US);
Minyong LI, Shandong, CN;
Shilong Zheng, Atlanta, GA (US);
Yunfeng Cheng, Atlanta, GA (US);
Hanjing Peng, Chamblee, GA (US);
Binghe Wang, Marietta, GA (US);
Nanting Ni, Atlanta, GA (US);
Junfeng Wang, Beijing, CN;
Chung-Dar Lu, Roswell, GA (US);
Han-Ting Chou, Atlanta, GA (US);
Minyong Li, Shandong, CN;
Shilong Zheng, Atlanta, GA (US);
Yunfeng Cheng, Atlanta, GA (US);
Hanjing Peng, Chamblee, GA (US);
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Abstract
The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.