The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2014
Filed:
Apr. 24, 2012
Georg Jaeschke, Basel, CH;
Synese Jolidon, Blauen, CH;
Lothar Lindemann, Basel, CH;
Antonio Ricci, Birsfelden, CH;
Daniel Rueher, Raedersdorf, FR;
Heinz Stadler, Basel, CH;
Eric Vieira, Frenkendorf, CH;
Georg Jaeschke, Basel, CH;
Synese Jolidon, Blauen, CH;
Lothar Lindemann, Basel, CH;
Antonio Ricci, Birsfelden, CH;
Daniel Rueher, Raedersdorf, FR;
Heinz Stadler, Basel, CH;
Eric Vieira, Frenkendorf, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to ethynyl derivatives of formula I wherein G, X, R, R, R, R, R, and Rare as defined hereinor to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).