The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2014
Filed:
Nov. 15, 2006
Masaji Okada, Osaka, JP;
Masafumi Takahashi, Nagano, JP;
Atsushi Izawa, Nagano, JP;
Yoshiyuki Ohsugi, Tokyo, JP;
Masahiko Mihara, Shizuoka, JP;
Masaji Okada, Osaka, JP;
Masafumi Takahashi, Nagano, JP;
Atsushi Izawa, Nagano, JP;
Yoshiyuki Ohsugi, Tokyo, JP;
Masahiko Mihara, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
National Hospital Organization, Tokyo, JP;
Shinshu University, Nagano, JP;
Abstract
The effect of anti-IL-6 receptor antibodies in suppressing cytotoxic T cell induction was examined. The results showed that CTL activity against alloantigens was statistically significantly reduced in mice treated with anti-IL-6 receptor antibodies as compared to mice not treated with antibodies and mice treated with a control antibody. The anti-IL-6 receptor antibody was also administered to recipients of a mouse model for allogenic heart transplantation. As a result, histopathological findings showed that inflammatory cell infiltration into transplanted hearts was suppressed and the survival period of transplanted hearts was significantly prolonged. Thus, the present inventors for the first time discovered that administration of anti-IL-6 receptor antibodies could suppress cytotoxic T cell induction and thereby suppress acute rejection after transplantation.