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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8618296 B1

PDFFull Text
Date of Patent:
Dec. 31, 2013

Filed:

Jun. 10, 2013

Arylethynyl derivatives

Applicant:

Hoffmann-la Roche Inc., Nutley, NJ (US);

Inventors:

Luke Green, Basel, CH;

Wolfgang Guba, Muelheim, DE;

Georg Jaeschke, Basel, CH;

Synese Jolidon, Blauen, CH;

Lothar Lindemann, Basel, CH;

Antonio Ricci, Birsfelden, CH;

Daniel Rueher, Raedersdorf, FR;

Heinz Stadler, Basel, CH;

Eric Vieira, Frenkendorf, CH;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorney:
Primary Examiner:

Rita Desai

Assistant Examiner:

Ben S Michelson

Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/501 (2006.01); A61K 31/4965 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); A61K 31/44 (2006.01); C07D 237/00 (2006.01); C07D 239/00 (2006.01); C07D 241/00 (2006.01); C07D 401/00 (2006.01); C07D 403/00 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 239/02 (2006.01); C07D 241/02 (2006.01); C07D 211/00 (2006.01); C07D 213/00 (2006.01); C07D 215/00 (2006.01); C07D 217/00 (2006.01); C07D 219/00 (2006.01); C07D 221/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to ethynyl compounds of formula I whereinR1, R2, R2', R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

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