The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Aug. 19, 2009
Mark Cunningham, Radnor, PA (US);
Bethany Swencki-underwood, Radnor, PA (US);
Yi Tang, Radnor, PA (US);
LI Yan, Berwyn, PA (US);
Mark Cunningham, Radnor, PA (US);
Bethany Swencki-Underwood, Radnor, PA (US);
Yi Tang, Radnor, PA (US);
Li Yan, Berwyn, PA (US);
Centocor Ortho Biotech Inc., Horsham, PA (US);
Abstract
The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.