The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Dec. 13, 2010
Graham K. Farrington, Acton, MA (US);
Alexey Alexandrovich Lugovskoy, Woburn, MA (US);
Werner Meier, Burlington, MA (US);
John K. Eldredge, South Chatham, MA (US);
Ellen Garber, Cambridge, MA (US);
Graham K. Farrington, Acton, MA (US);
Alexey Alexandrovich Lugovskoy, Woburn, MA (US);
Werner Meier, Burlington, MA (US);
John K. Eldredge, South Chatham, MA (US);
Ellen Garber, Cambridge, MA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.