The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Jan. 09, 2009
Kenji Uehara, Kikuchi, JP;
Hirofumi Higuchi, Kikuchi, JP;
Toshihiro Nakashima, Kikuchi, JP;
Daisuke Ishikawa, Kikuchi, JP;
Nobuchika Yamamoto, Tokyo, JP;
Hirotada Fujita, Tokyo, JP;
Fumihiko Sakai, Tokyo, JP;
Kenji Uehara, Kikuchi, JP;
Hirofumi Higuchi, Kikuchi, JP;
Toshihiro Nakashima, Kikuchi, JP;
Daisuke Ishikawa, Kikuchi, JP;
Nobuchika Yamamoto, Tokyo, JP;
Hirotada Fujita, Tokyo, JP;
Fumihiko Sakai, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.