The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2013
Filed:
Oct. 31, 2005
Alicja Bielawska, Charleston, SC (US);
Yusuf A. Hannun, Sullivan's Island, SC (US);
James Norris, Mount Pleasant, SC (US);
Zdzislaw M. Szulc, Charleston, SC (US);
Jian-yun Dong, Mount Pleasant, SC (US);
Jacek Bielawski, Charleston, SC (US);
David A. Schwartz, Summerville, SC (US);
David H. Holman, Charleston, SC (US);
Ahmed M. El-zawahry, Charleston, SC (US);
John Mckillop, Charleston, SC (US);
Alicja Bielawska, Charleston, SC (US);
Yusuf A. Hannun, Sullivan's Island, SC (US);
James Norris, Mount Pleasant, SC (US);
Zdzislaw M. Szulc, Charleston, SC (US);
Jian-yun Dong, Mount Pleasant, SC (US);
Jacek Bielawski, Charleston, SC (US);
David A. Schwartz, Summerville, SC (US);
David H. Holman, Charleston, SC (US);
Ahmed M. El-Zawahry, Charleston, SC (US);
John McKillop, Charleston, SC (US);
MUSC Foundation for Research Development, Charleston, SC (US);
Abstract
The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R, R, R, R, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.