The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Mar. 05, 2012
K. Barry Sharpless, La Jolla, CA (US);
Valery Fokin, Oceanside, CA (US);
Vsevold V. Rostovtsev, Wilmington, DE (US);
Luke Green, Basel, CH;
Fahmi Himo, Solna, SE;
K. Barry Sharpless, La Jolla, CA (US);
Valery Fokin, Oceanside, CA (US);
Vsevold V. Rostovtsev, Wilmington, DE (US);
Luke Green, Basel, CH;
Fahmi Himo, Solna, SE;
The Scripps Research Institute, La Jolla, CA (US);
Abstract
A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.