The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Jul. 02, 2007
Masaru Miyagi, Shaker Heights, OH (US);
Masaru Miyagi, Shaker Heights, OH (US);
The University of North Dakota, Grand Forks, ND (US);
Abstract
A method for comparative proteomics using a peptidase under enzymatic conditions that permits the optimal incorporation of two oxygen atoms into a digested peptide. The method employs a peptidase to incorporate twoO atoms into a peptide set derived from a population of proteins at a conditioned state, which is compared to a second peptide set incorporated with a singleO atom derived from a population of proteins at a second conditioned state. Upon combining the two peptide sets, the populations of proteins are analyzed for qualitative and quantitative differences based on the content ofO atoms andO atoms in the digested peptides using mass spectrometry instrumentation. The method is advantageous to improve the efficiency and timeframe of peptidase catalyzedO labeling reactions which increased the accuracy and reliability of quantitative proteomic experiments.