The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Feb. 17, 2012
Applicants:
Jonathan Lebowitz, Novato, CA (US);
John Maga, Whitefish Bay, WI (US);
Inventors:
Jonathan LeBowitz, Novato, CA (US);
John Maga, Whitefish Bay, WI (US);
Assignee:
Biomarin Pharmaceutical, Inc., Novato, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.