The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2013
Filed:
Sep. 27, 2010
Reiko Takasaka Lee, Baltimore, MD (US);
Yuan-chuan Lee, Baltimore, MD (US);
Mei-hui Wang, Taoyuan County, TW;
Wuu-jyh Lin, Taoyuan County, TW;
Reiko Takasaka Lee, Baltimore, MD (US);
Yuan-Chuan Lee, Baltimore, MD (US);
Mei-Hui Wang, Taoyuan County, TW;
Wuu-Jyh Lin, Taoyuan County, TW;
Johns Hopkins University, Baltimore, MD (US);
Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan, Taoyuan County, TW;
Abstract
This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilotriacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N-benzyloxycarbonyl-N-dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 molecules of NTA(ahLac). This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higherIn-radiolabelling yield than those non-extended.