Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses

Abstract

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are —CH—O— or —O—CH—; or Rand Rtaken together are —CO—O—, —O—CO—, —CH—O— or —O—CH—; Ris hydrogen, or Rand Rtogether form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.