The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Mar. 06, 2008
Jacob Fog Bentzon, Horsens, DK;
Charlotte Brandt Sørensen, Højbjerg, DK;
Peter Michael Kragh, Trondheim, NO;
Jacob Giehm Mikkelsen, Silkeborg, DK;
Erling Falk, Harlev, DK;
Lars Axel Bolund, Skødstrup, DK;
Thomas Juhl Corydon, Risskov, DK;
Jacob Fog Bentzon, Horsens, DK;
Charlotte Brandt Sørensen, Højbjerg, DK;
Peter Michael Kragh, Trondheim, NO;
Jacob Giehm Mikkelsen, Silkeborg, DK;
Erling Falk, Harlev, DK;
Lars Axel Bolund, Skødstrup, DK;
Thomas Juhl Corydon, Risskov, DK;
Aarhus Universitet, , DK;
Abstract
The present invention relates to a genetically modified pig as a model for studying atherosclerosis. The modified pig model displays one or more phenotypes associated with atherosclerosis. Disclosed is also a modified pig comprising a mutation in the endogenous ApoE gene or part thereof, LDL gene or part thereof, LDL receptor gene, or transcriptional or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of atherosclerosis; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from atherosclerosis are disclosed.