The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Apr. 01, 2009
Hiromitsu Nakauchi, Tokyo, JP;
Koji Eto, Tokyo, JP;
Hidekazu Nishiki-i, Tokyo, JP;
Naoya Takayama, Tokyo, JP;
Shinya Yamanaka, Kyoto, JP;
Kazutoshi Takahashi, Kyoto, JP;
Hiromitsu Nakauchi, Tokyo, JP;
Koji Eto, Tokyo, JP;
Hidekazu Nishiki-I, Tokyo, JP;
Naoya Takayama, Tokyo, JP;
Shinya Yamanaka, Kyoto, JP;
Kazutoshi Takahashi, Kyoto, JP;
The University of Tokyo, Tokyo, JP;
Abstract
A method for efficiently preparing blood cells, such as mature megakaryocytes and platelets, from iPS cells is achieved in an in vitro culture system. A sac-like structure encloses hematopoietic progenitor cells, which is obtained by inoculating iPS cells onto feeder cells and then culturing the iPS cells under conditions suitable for inducing the differentiation of hematopoietic progenitor cells. Moreover, a method for producing various types of blood cells, comprises culturing hematopoietic progenitor cells enclosed in the sac-like structure under conditions suitable for inducing the differentiation of blood cells. Furthermore, a method for producing various types of blood cells, particularly megakaryocytes and platelets, is achieved without involving the sac-like structure.