The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Apr. 19, 2012
Kevin Kunnen, Plymouth, IN (US);
Nathan W. Stehle, St. Charles, IL (US);
Scot W. Weis, Milwaukee, WI (US);
John M. Pascone, Grafton, WI (US);
Richard J. Pariza, Zion, IL (US);
Scott G. Van Ornum, Jackson, WI (US);
Paul Zizelman, Grafton, WI (US);
Kevin Kunnen, Plymouth, IN (US);
Nathan W. Stehle, St. Charles, IL (US);
Scot W. Weis, Milwaukee, WI (US);
John M. Pascone, Grafton, WI (US);
Richard J. Pariza, Zion, IL (US);
Scott G. Van Ornum, Jackson, WI (US);
Paul Zizelman, Grafton, WI (US);
Cedarburg Pharmaceuticals, Inc., Grafton, WI (US);
Abstract
A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R, R, R, R, independently, is hydrogen, halogen or C-Calkyl. In one form, the aromatase inhibitor is exemestane wherein each of R, R, R, Ris hydrogen. In the method, a compound of formula (II) wherein R, R, R, Rare as defined above and R is alkylene, is reacted with a deprotonating agent and a compound of the formula RSOX wherein Ris C-Calkyl and X is halogen so as to obtain a compound of formula (III) wherein R, R, R, R, Rare as defined above. The compound of Formula (III) is then reacted with a base to form an aromatase inhibitor of formula (I).