The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
May. 14, 2009
Lori Emert-sedlak, Cranberry Twp., PA (US);
Toshiaki Kodama, Sunnyvale, CA (US);
Billy W. Day, Pittsburgh, PA (US);
Weixiang Dai, Morgantown, WV (US);
Ronald P. Trible, Atlanta, GA (US);
Thomas E. Smithgall, Wexford, PA (US);
Lori Emert-Sedlak, Cranberry Twp., PA (US);
Toshiaki Kodama, Sunnyvale, CA (US);
Billy W. Day, Pittsburgh, PA (US);
Weixiang Dai, Morgantown, WV (US);
Ronald P. Trible, Atlanta, GA (US);
Thomas E. Smithgall, Wexford, PA (US);
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.