The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
May. 02, 2007
David W. Ruff, San Francisco, CA (US);
Mark E. Shannon, San Francisco, CA (US);
Kenneth J. Livak, San Jose, CA (US);
Karl J. Guegler, Menlo Park, CA (US);
Kevin M. Hennessy, San Mateo, CA (US);
David W. Ruff, San Francisco, CA (US);
Mark E. Shannon, San Francisco, CA (US);
Kenneth J. Livak, San Jose, CA (US);
Karl J. Guegler, Menlo Park, CA (US);
Kevin M. Hennessy, San Mateo, CA (US);
Applied Biosystems, LLC, Carlsbad, CA (US);
Abstract
The present teachings provide methods, compositions, and kits for detecting the presence of protein aggregates. In some embodiments, the protein aggregate is treated with a labeled precursor, and the labeled precursor is incorporated into the protein aggregate to form a labeled protein aggregate. The labeled protein aggregate is then measured, thus detecting the presence of the protein aggregate. In some embodiments, the labeled protein aggregate is detected by interaction of labeled precursors, for example by a proximity ligation assay.