The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
Oct. 01, 2008
Bonnie Bassler, Princeton, NJ (US);
Martin Semmelhack, Princeton, NJ (US);
Douglas A. Higgins, Point Pleasant, NJ (US);
Megan Eileen Bolitho, San Mateo, CA (US);
Kristina M. Kraml, Princeton, NJ (US);
Wai-leung NG, Lawrenceville, NJ (US);
Bonnie Bassler, Princeton, NJ (US);
Martin Semmelhack, Princeton, NJ (US);
Douglas A. Higgins, Point Pleasant, NJ (US);
Megan Eileen Bolitho, San Mateo, CA (US);
Kristina M. Kraml, Princeton, NJ (US);
Wai-Leung Ng, Lawrenceville, NJ (US);
The Trustees of Princeton University, Princeton, NJ (US);
Abstract
A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.