The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2013
Filed:
Jul. 15, 2005
Patrick Hoffmann, München, DE;
Silke Mittelstrass, München, DE;
Jens Hennecke, München, DE;
Tobias Raum, München, DE;
Patrick Hoffmann, München, DE;
Silke Mittelstrass, München, DE;
Jens Hennecke, München, DE;
Tobias Raum, München, DE;
Amgen Research (Munich) GmbH, Munich, DE;
Abstract
A composite polypeptide, said composite polypeptide comprising a desired polypeptide and an expression enhancing domain ('EED'), said EED comprising first and second cysteine amino acid residues Cys1 and Cys2, respectively, Cys1 being located closer to the N-terminus of the composite polypeptide molecule than Cys2, wherein Cys1 and Cys2 are separated by a polypeptide linker, said linker—being free of cysteine and proline;—defining a length sufficient to allow Cys1 and Cys2 to engage in an intramolecular disulfide bond with one another; and—having a flexible polypeptide conformation essentially free of secondary polypeptide structure in aqueous solution, wherein at least one of Cys1 and Cys2 is derivatized with a derivatization moiety.