The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2013
Filed:
May. 03, 2010
John J. Rossi, Alta Loma, CA (US);
Daniela Castanotto, Altadena, CA (US);
Gerd Pfeifer, Bradbury, CA (US);
Stella Tommasi, South Pasadena, CA (US);
Kevin V. Morris, Sierra Madre, CA (US);
Daniel H. Kim, Duarte, CA (US);
John J. Rossi, Alta Loma, CA (US);
Daniela Castanotto, Altadena, CA (US);
Gerd Pfeifer, Bradbury, CA (US);
Stella Tommasi, South Pasadena, CA (US);
Kevin V. Morris, Sierra Madre, CA (US);
Daniel H. Kim, Duarte, CA (US);
City of Hope, Duarte, CA (US);
Abstract
The present invention relates to transcriptional gene silencing (TGS) in mammalian, including human, cells that is mediated by small interfering RNA (siRNA) molecules. The present invention also relates to a double stranded nucleic acid that directs methylation of histones associated with target genes that produce low copy promoter-specific RNA. It has been found that siRNAs can be used to direct methylation of histones in mammalian, including human, cells.