The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Sep. 26, 2008
Tomoyuki Igawa, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Hirotake Shiraiwa, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Takahiro Ishiguro, Kanagawa, JP;
Tomoyuki Igawa, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Hirotake Shiraiwa, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Takahiro Ishiguro, Kanagawa, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient.