The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Aug. 10, 2007
Sarah L. Pogue, Fremont, CA (US);
Alan J. Korman, Piedmont, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Mohan Srinivasan, Cupertino, CA (US);
Bingliang Chen, Alameda, CA (US);
Alasdair F. Bell, Mountain View, CA (US);
Sarah L. Pogue, Fremont, CA (US);
Alan J. Korman, Piedmont, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Mohan Srinivasan, Cupertino, CA (US);
Bingliang Chen, Alameda, CA (US);
Alasdair F. Bell, Mountain View, CA (US);
Medarex, Inc., Princeton, NJ (US);
Ono Pharmaceutical Co., Ltd., Osaka, JP;
Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.