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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8492381 B1

PDFFull Text
Date of Patent:
Jul. 23, 2013

Filed:

Nov. 14, 2011

Pyrazino[2,3-b]pyrazine mtor kinase inhibitor for oncology indications and diseases associated with the mtor/pi3k/akt pathway

Applicants:

Sophie Perrin-ninkovic, La Jolla, CA (US);

Roy L. Harris, San Diego, CA (US);

John Sapienza, Chula Vista, CA (US);

Graziella Shevlin, San Diego, CA (US);

Patrick Papa, Carlsbad, CA (US);

Branden Lee, Encinitas, CA (US);

Garrick Packard, San Diego, CA (US);

Lida Tehrani, San Diego, CA (US);

Jingjing Zhao, San Diego, CA (US);

Jennifer Riggs, Cardiff, CA (US);

Jason Parnes, San Diego, CA (US);

Deborah Mortensen, San Diego, CA (US);

Weiming Xu, San Diego, CA (US);

Loui Madakamutil, San Diego, CA (US);

Kimberly Fultz, San Diego, CA (US);

Rama K. Narla, San Diego, CA (US);

Sabita Sankar, San Diego, CA (US);

Jan Elsner, San Diego, CA (US);

Inventors:

Sophie Perrin-Ninkovic, La Jolla, CA (US);

Roy L. Harris, San Diego, CA (US);

John Sapienza, Chula Vista, CA (US);

Graziella Shevlin, San Diego, CA (US);

Patrick Papa, Carlsbad, CA (US);

Branden Lee, Encinitas, CA (US);

Garrick Packard, San Diego, CA (US);

Lida Tehrani, San Diego, CA (US);

Jingjing Zhao, San Diego, CA (US);

Jennifer Riggs, Cardiff, CA (US);

Jason Parnes, San Diego, CA (US);

Deborah Mortensen, San Diego, CA (US);

Weiming Xu, San Diego, CA (US);

Loui Madakamutil, San Diego, CA (US);

Kimberly Fultz, San Diego, CA (US);

Rama K. Narla, San Diego, CA (US);

Sabita Sankar, San Diego, CA (US);

Jan Elsner, San Diego, CA (US);

Assignee:

Signal Pharmaceuticals, LLC, San Diego, CA (US);

Attorney:

Jones Day

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/497 (2006.01);
U.S. Cl.
CPC ...
Abstract

Provided herein are Heteroaryl Compounds having the following structure:

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