The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2013
Filed:
Jun. 18, 2008
Erin Lavik, Branford, CT (US);
Young H. Kwon, Iowa City, IA (US);
Markus Kuehn, Amana, IA (US);
Sandeep Saluja, Fair Lawn, NJ (US);
James Bertram, New Haven, CT (US);
John Huang, Hamden, CT (US);
Erin Lavik, Branford, CT (US);
Young H. Kwon, Iowa City, IA (US);
Markus Kuehn, Amana, IA (US);
Sandeep Saluja, Fair Lawn, NJ (US);
James Bertram, New Haven, CT (US);
John Huang, Hamden, CT (US);
Yale University, New Haven, CT (US);
University of Iowa Research Foundation, Iowa City, IA (US);
Abstract
Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing one or more diseases or disorders of the eye, and methods of making and using thereof, are described. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (IOP) in the eye. Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time.