The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Jan. 15, 2009
Timothy A. Blizzard, Princeton, NJ (US);
Helen Chen, Marlboro, NJ (US);
Candido Gude, Staten Island, NY (US);
Jeffrey D. Hermes, Warren, NJ (US);
Jason Imbriglio, Piscataway, NJ (US);
Seongkon Kim, Holmdel, NJ (US);
Jane Y. Wu, Marlboro, NJ (US);
Christopher J. Mortko, Hoboken, NJ (US);
Ian Mangion, Cranford, NJ (US);
Nelo Rivera, New Milford, NJ (US);
Rebecca T. Ruck, Jersey City, NJ (US);
Michael Shevlin, Plainfield, NJ (US);
Timothy A. Blizzard, Princeton, NJ (US);
Helen Chen, Marlboro, NJ (US);
Candido Gude, Staten Island, NY (US);
Jeffrey D. Hermes, Warren, NJ (US);
Jason Imbriglio, Piscataway, NJ (US);
Seongkon Kim, Holmdel, NJ (US);
Jane Y. Wu, Marlboro, NJ (US);
Christopher J. Mortko, Hoboken, NJ (US);
Ian Mangion, Cranford, NJ (US);
Nelo Rivera, New Milford, NJ (US);
Rebecca T. Ruck, Jersey City, NJ (US);
Michael Shevlin, Plainfield, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Substituted bicyclic beta-lactams of Formula I: (I), are β-lactamase inhibitors, wherein a, X, Rand Rare defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds can be employed with a β-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.