The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2013
Filed:
Jun. 19, 2008
Ronen Marmorstein, Swarthmore, PA (US);
Xin Liu, Menlo Park, CA (US);
Philip A. Cole, Baltimore, MD (US);
Ling Wang, Seattle, WA (US);
Erin M. Bowers, Baltimore, MD (US);
David J. Meyers, Towson, MD (US);
Chandrani Mukherjee, Baltimore, MD (US);
Ronen Marmorstein, Swarthmore, PA (US);
Xin Liu, Menlo Park, CA (US);
Philip A. Cole, Baltimore, MD (US);
Ling Wang, Seattle, WA (US);
Erin M. Bowers, Baltimore, MD (US);
David J. Meyers, Towson, MD (US);
Chandrani Mukherjee, Baltimore, MD (US);
The Wistar Institute, Philadelphia, PA (US);
The John Hopkins University, Baltimore, MD (US);
Abstract
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.