The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
Dec. 22, 2009
Yusuke Suzuki, Osaka, JP;
Hiroshi Tahara, Osaka, JP;
Keiichi Yamamoto, Osaka, JP;
Yuzuru Kitahara, Osaka, JP;
Yasuhiko Suzuki, Sapporo, JP;
Yusuke Suzuki, Osaka, JP;
Hiroshi Tahara, Osaka, JP;
Keiichi Yamamoto, Osaka, JP;
Yuzuru Kitahara, Osaka, JP;
Yasuhiko Suzuki, Sapporo, JP;
National University Corporation Hokkaido University, Hokkaido, JP;
Fuso Pharmaceutical Industries, Ltd., Osaka, JP;
Abstract
As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.