The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
Oct. 13, 2010
Josephine M. Cardarelli, San Carlos, CA (US);
David B. Passmore, San Carlos, CA (US);
Jenny Albanese, South Lake Tahoe, CA (US);
Lei Zhu, Bellevue, WA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
David B. Passmore, San Carlos, CA (US);
Jenny Albanese, South Lake Tahoe, CA (US);
Lei Zhu, Bellevue, WA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMAcells, such as tumor cells, are also provided.