The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
Sep. 13, 2007
Guanghui MA, Beijing, CN;
Zhiguo Su, Beijing, CN;
Wei Wei, Beijing, CN;
Lianyan Wang, Beijing, CN;
Qiang Wei, Beijing, CN;
Guanghui Ma, Beijing, CN;
Zhiguo Su, Beijing, CN;
Wei Wei, Beijing, CN;
Lianyan Wang, Beijing, CN;
Qiang Wei, Beijing, CN;
Abstract
A method of fluorescence imaging is disclosed that uses a non-labeled fluorescent microsphere comprising a primary amine polymer, wherein the microsphere does not contain an additional fluorescent substance, and wherein at least one primary amine group in the primary amine polymer has the structure of —N═R—, in which R is a residue after the reaction of an aldehyde-type cross-linking substance, and the other primary amine groups have the structure of —NH. The fluorescence color of the microspheres can be adjusted by selecting different aldehyde-type cross-linking substances or combinations, and the fluorescence intensity of the microspheres can be controlled not only by the addition of the aldehyde-type cross-linking substances and the time of the cross-linking reaction, but also by adjusting the diameters of the microspheres.