The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2013

Filed:

Mar. 22, 2007
Applicants:

Pavel A. Pevzner, La Jolla, CA (US);

Nuno F. C. Bandeira, La Jolla, CA (US);

Dekel Tsur, Be'er Sheva, IL;

Inventors:

Pavel A. Pevzner, La Jolla, CA (US);

Nuno F. C. Bandeira, La Jolla, CA (US);

Dekel Tsur, Be'er Sheva, IL;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); G01N 31/00 (2006.01); G01B 3/00 (2006.01); G06F 7/60 (2006.01); G06F 19/00 (2006.01);
U.S. Cl.
CPC ...
G06F 19/00 (2013.01);
Abstract

Protein samples are processed to create a mixture of modified and unmodified or overlapping peptides which are analyzed using mass spectrometry. Correlations between the MS/MS spectra of peptide pairs allow the noise in individual MS/MS spectra to be greatly reduced. A small number of peptide reconstructions can be generated that are likely to contain the correct one. This allows for the de novo reconstruction of protein sequences and peptide and modification identification through a database search using extremely fast pattern matching, rather than time-consuming matching of spectra against databases.


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