The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Oct. 01, 2007
Michelle Kuhne, San Francisco, CA (US);
Peter Brams, Sacramento, CA (US);
Dawn M. Tanamachi, San Carlos, CA (US);
Alan J. Korman, Piedmont, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Michelle Kuhne, San Francisco, CA (US);
Peter Brams, Sacramento, CA (US);
Dawn M. Tanamachi, San Carlos, CA (US);
Alan J. Korman, Piedmont, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.