The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2013
Filed:
Mar. 17, 2010
Zhenjun Diwu, Sunnyvale, CA (US);
Timothy Dubrovsky, Davis, CA (US);
Barnaby Abrams, San Carlos, CA (US);
Jinfang Liao, Foster City, CA (US);
Qinglin Meng, Sunnyvale, CA (US);
Zhenjun Diwu, Sunnyvale, CA (US);
Timothy Dubrovsky, Davis, CA (US);
Barnaby Abrams, San Carlos, CA (US);
Jinfang Liao, Foster City, CA (US);
Qinglin Meng, Sunnyvale, CA (US);
Becton, Dickinson and Company, Franklin Lakes, NJ (US);
Abstract
Chemically-reactive, water-soluble, heterocycle-substituted 7-hydroxycoumarin dyes, their bioconjugates and uses are described. The conjugates derived from reactive heterocycle-substituted 7-hydroxycoumarin dyes are used for analyzing biological compounds. These heterocycle-substituted 7-hydroxycoumarin dyes are particularly useful as fluorescent labels for biopolymer detection reagents, such as antibodies or nucleic acid probes. The dye-antibody conjugates of the invention are particularly useful for analyzing analytes using a flow cytometer equipped with a violet laser as an excitation source due to their strong absorption at 405 nm and high fluorescence quantum yield.