The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2013
Filed:
Jun. 04, 2008
Amy C. Anderson, Storrs, CT (US);
Dennis L. Wright, Storrs, CT (US);
Phillip M. Pelphrey, Williamsville, NY (US);
Tammy M. Joska, Hartford, VT (US);
Erin S. D. Bolstad, Vernon, CT (US);
David B. Bolstad, Vernon, CT (US);
Veljko Popov, Hanover, NH (US);
Amy C. Anderson, Storrs, CT (US);
Dennis L. Wright, Storrs, CT (US);
Phillip M. Pelphrey, Williamsville, NY (US);
Tammy M. Joska, Hartford, VT (US);
Erin S. D. Bolstad, Vernon, CT (US);
David B. Bolstad, Vernon, CT (US);
Veljko Popov, Hanover, NH (US);
University of Connecticut, Farmington, CT (US);
Abstract
The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such asand methicillin-resistant, fungi such asandand protozoa such asand. These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.