The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Mar. 03, 2004
Balkrishen Bhat, Carlsbad, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Charles Allerson, San Diego, CA (US);
Prasad Dande, Cambridge, MA (US);
Richard H. Griffey, Vista, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Charles Allerson, San Diego, CA (US);
Prasad Dande, Cambridge, MA (US);
Richard H. Griffey, Vista, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment the oligomeric compounds comprise double stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.