The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Dec. 21, 2006
Ralf Lutterbüse, Neuried, DE;
Petra Mayer, München, DE;
Evelyne Schaller, Sauerlach, DE;
Doris Rau, Unterhaching, DE;
Susanne Mangold, München, DE;
Peter Kufer, Moosburg, DE;
Alexander Murr, München, DE;
Tobias Raum, München, DE;
Monika Wissinger, Gilching, DE;
Ralf Lutterbüse, Neuried, DE;
Petra Mayer, München, DE;
Evelyne Schaller, Sauerlach, DE;
Doris Rau, Unterhaching, DE;
Susanne Mangold, München, DE;
Peter Kufer, Moosburg, DE;
Alexander Murr, München, DE;
Tobias Raum, München, DE;
Monika Wissinger, Gilching, DE;
Micromet AG, Munich, DE;
Abstract
The present disclosure relates to a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, where the second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7, a pharmaceutical composition comprising the bispecific single chain antibody, and methods for the treatment of an epithelial tumor in a human with the pharmaceutical compositions containing the bispecific single chain antibody. Furthermore, processes for the production of the pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed.