The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Jul. 31, 2007
Stephen H. Leppla, Bethesda, MD (US);
Mary JO Rosovitz, Germantown, MD (US);
John B. Robbins, New York, NY (US);
Rachel Schneerson, Bethesda, MD (US);
S. Dana Hsu, Bethesda, MD (US);
Joseph Shiloach, Rockville, MD (US);
Delia M. Ramirez, Bethesda, MD (US);
Stephen H. Leppla, Bethesda, MD (US);
Mary Jo Rosovitz, Germantown, MD (US);
John B. Robbins, New York, NY (US);
Rachel Schneerson, Bethesda, MD (US);
S. Dana Hsu, Bethesda, MD (US);
Joseph Shiloach, Rockville, MD (US);
Delia M. Ramirez, Bethesda, MD (US);
Abstract
The invention relates to improved methods of producing and recovering sporulation-deficientmutant stains, and for producing and recovering recombinantprotective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of,bacterial infections and which are useful to prevent and/or treat illnesses caused by, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.