The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Oct. 27, 2009
Rene J. Trabanino, Los Angeles, CA (US);
Nagarajan Vaidehi, Arcadia, CA (US);
Spencer E. Hall, Tucson, AZ (US);
William A. Goddard, Pasadena, CA (US);
Wely Floriano, Pasadena, CA (US);
Rene J. Trabanino, Los Angeles, CA (US);
Nagarajan Vaidehi, Arcadia, CA (US);
Spencer E. Hall, Tucson, AZ (US);
William A. Goddard, Pasadena, CA (US);
Wely Floriano, Pasadena, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the presence of transmembrane regions in proteins, such as G-Protein Coupled Receptors (GPCR), and protein structural models generated according to the protocol. The protocol features a coarse grain sampling method, such as hydrophobicity analysis, to provide a fast and accurate procedure for predicting transmembrane regions. Methods and apparatus of the invention are useful to screen protein or polynucleotide databases for encoded proteins with transmembrane regions, such as GPCRs.