The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Sep. 15, 2006
Bruce A. Sullenger, Chapel Hill, NC (US);
Juliana M. Layzer, Durham, NC (US);
Christopher P. Rusconi, Durham, NC (US);
Sabah Oney, Durham, NC (US);
Nanette L. S. Que-gewirth, Buffalo, NY (US);
Bruce A. Sullenger, Chapel Hill, NC (US);
Juliana M. Layzer, Durham, NC (US);
Christopher P. Rusconi, Durham, NC (US);
Sabah Oney, Durham, NC (US);
Nanette L. S. Que-Gewirth, Buffalo, NY (US);
Duke University, Durham, NC (US);
Abstract
Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific binding to a target. Aptamers which are selected or derivatives thereof may be used for those specific activities in biological systems. Any combination of deconvoluting a focused library (functional profiling), increasing frequencies of particular aptamers in a focused library (Laser SELEX), and decreasing frequencies of particular aptamers in a focused library (DeSELEX) may be performed prior to assaying biological activity.