The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2013
Filed:
Jul. 28, 2006
Gillian Ashcroft, Manchester, GB;
Mario Brufani, Castelgandolfo, IT;
Francesca Ceccacci, Rome, IT;
Paolo Maria Farina, Milan, IT;
Luigi Filocamo, Rome, IT;
Barbara Garofalo, Rome, IT;
Roberta Joudioux, Rome, IT;
Adriana Maggi, Milan, IT;
Rinaldo Marini Bettolo, Rome, IT;
Luisa Maria Migneco, Rome, IT;
Gillian Ashcroft, Manchester, GB;
Mario Brufani, Castelgandolfo, IT;
Francesca Ceccacci, Rome, IT;
Paolo Maria Farina, Milan, IT;
Luigi Filocamo, Rome, IT;
Barbara Garofalo, Rome, IT;
Roberta Joudioux, Rome, IT;
Adriana Maggi, Milan, IT;
Rinaldo Marini Bettolo, Rome, IT;
Luisa Maria Migneco, Rome, IT;
Euticals S.p.A., , IT;
Abstract
The invention relates to 17α-(5-hydroxy-C-hydrocarbyl)-1,3,5(10)-estratrien-3,17β-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17α-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5'-esters and 3,5′-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-′ or 3,5′-esterifÊcation.