The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2012
Filed:
Jan. 27, 2005
David Knaack, Summit, NJ (US);
Michele Diegmann, Scotch Plains, NJ (US);
Albert Manrique, Manalapan, NJ (US);
Keyvan Benham, Red Bank, NJ (US);
David Knaack, Summit, NJ (US);
Michele Diegmann, Scotch Plains, NJ (US);
Albert Manrique, Manalapan, NJ (US);
Keyvan Benham, Red Bank, NJ (US);
Warsaw Orthopedic, Inc., Warsaw, IN (US);
Abstract
A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.