The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Sep. 03, 2009
Michael P. Belmares, Campbell, CA (US);
Jonathan David Garman, San Jose, CA (US);
Peter S. LU, Palo Alto, CA (US);
Michael W. Salter, Toronto, CA;
Michael Tymianski, Toronto, CA;
Michael P. Belmares, Campbell, CA (US);
Jonathan David Garman, San Jose, CA (US);
Peter S. Lu, Palo Alto, CA (US);
Michael W. Salter, Toronto, CA;
Michael Tymianski, Toronto, CA;
NoNO Inc., Toronto, Ontario, CA;
Abstract
The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.