The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Dec. 22, 2006
Bruce Paul Davidson, Singapore, SG;
Ralph Eberhard Graichen, Singapore, SG;
Robert Zweigerdt, Singapore, SG;
Xiuqin Xu, Singapore, SG;
Christine Lindsay Mummery, DJ Bilthoven, NL;
William Sun, Singapore, SG;
Bruce Paul Davidson, Singapore, SG;
Ralph Eberhard Graichen, Singapore, SG;
Robert Zweigerdt, Singapore, SG;
Xiuqin Xu, Singapore, SG;
Christine Lindsay Mummery, DJ Bilthoven, NL;
William Sun, Singapore, SG;
Other;
Abstract
The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.