The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2012
Filed:
Dec. 14, 2005
James Gair Ford, Macclesfield, GB;
James Francis Mccabe, Macclesfield, GB;
Anne O'kearney-mcmullan, Macclesfield, GB;
Simon Mark Pointon, Macclesfield, GB;
Lyn Powell, Macclesfield, GB;
Philip O'keefe, Loughborough, GB;
Mark Purdie, Loughborough, GB;
Jane Withnall, Loughborough, GB;
James Gair Ford, Macclesfield, GB;
James Francis McCabe, Macclesfield, GB;
Anne O'Kearney-McMullan, Macclesfield, GB;
Simon Mark Pointon, Macclesfield, GB;
Lyn Powell, Macclesfield, GB;
Philip O'Keefe, Loughborough, GB;
Mark Purdie, Loughborough, GB;
Jane Withnall, Loughborough, GB;
AstraZeneca AB, Sodertalje, SE;
Abstract
The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-tetrahydropyran-4-yloxyquinazoline (the active entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containing such crystalline forms.