The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Jul. 09, 2008
Christoph Kobler, Alzenau, DE;
Martin Hateley, Munich, DE;
Philipp Roth, Hanau, DE;
Barbara Jaeger, Mainhausen, DE;
Christoph Weckbecker, Gruendau-Lieblos, DE;
Klaus Huthmacher, Gelnhausen, DE;
Christoph Kobler, Alzenau, DE;
Martin Hateley, Munich, DE;
Philipp Roth, Hanau, DE;
Barbara Jaeger, Mainhausen, DE;
Christoph Weckbecker, Gruendau-Lieblos, DE;
Klaus Huthmacher, Gelnhausen, DE;
Evonik Degussa GmbH, Essen, DE;
Abstract
A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.