The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2012
Filed:
Sep. 08, 2008
Lishan Chen, Bellevue, WA (US);
Kunyuan Cui, Bothell, WA (US);
Yuching Chen, Bellevue, WA (US);
Sasha J. Mayer, Snohomish, WA (US);
Michael E. Houston, Jr., Sammamish, WA (US);
Lishan Chen, Bellevue, WA (US);
Kunyuan Cui, Bothell, WA (US);
Yuching Chen, Bellevue, WA (US);
Sasha J. Mayer, Snohomish, WA (US);
Michael E. Houston, Jr., Sammamish, WA (US);
Marina Biotech, Inc., Bothell, WA (US);
Abstract
Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered.